Tuesday, 14 December 2010

Priapism

Priapism is a potentially harmful and painful condition brought about as a result of having an erection for an extended period of time (over four hours). The condition usually comes about despite the lack of physical or mental stimulation and is a medical emergency.

Priapism can arrise via various different neurological and vascular factors. Men with spinal injuries have been known to suffer from priapism. 35% of male sufferers of sickle-cell disease have experienced it (click). Intra-cavernous injections for the treatment of erectile dysfunction can also cause priapism as can some anti depressants.

An extended erection can cause damage to the tissue and blood vessels within the penis. This can result in erectile dysfunction, impotence or in extreme cases, gangrene. Immediate hospital treatment should be sought if you experience prispism, as there are various options for helping to reverse the priapic state. If reversal is not achieved quickly, corporal fibrosis can occur, which can result in peyronie's disease like symptoms.

In men damaged as a result of priapism there is however some hope. In this study, two men who suffered from priapism of greater than 48-hour duration benefited from a treatment also used to treat peyronie's disease, the PAV cocktail. The PAV cocktail consists of Pentoxifylline, L-arginine and Viagra, and through increasing nitric oxide production can have an antifibrotic effect.

The study notes that "At 1 year, both patients were found to have supple corpora without evidence of corporal fibrosis.". It's a shame there aren't more studies into this particular treatment regimen for priapism at this time, but it at least provides a long term treatment option, on top of the well understood emergency ones.

Sunday, 12 December 2010

Peyreton

Recently I saw a forum post from a man concerned that a herbal supplement called Peyreton, had not helped his condition at all. Unfortunately it's no surprise that it doesn't work, as this thread on the peyronie's forum attests.

On the Peyreton site, the 'Ingredient Details' are listed as:



None of these ingredients have ever been shown to be at all useful in any reliable, peer reviewed peyronie's disease study. It's as if the ingredients were randomly thrown together and I fail to see how they are at all useful in treating peyronie's disease. It has the hallmarks of a scam.

The Peyreton site also includes an 'Expected Results' area:



Unfortunely no oral treatment in existence can boast the ability to effectively cure peyronie's disease within a three month period. This claim is entirely without merit and gives men false hope.

The 'Research Studies' on the site are carried out by 'The Gordon's Herbal Research Center'. A quick google on that topic reveals this post. It appears that the ingredients for many of their miracle cures (for widly different conditions) are either identical or very similiar. The site even states concerns that thse supplements may even be dangerous to some individuals.

My advice would be to avoid Peyreton and any product under the Gordon's Herbal Research Center umbrella. Peyreton certainly will not help treat peyronie's disease. What it will do is waste your time, money and result in disappointment. It's a scam. Avoid.

Friday, 10 December 2010

Email - Penis Bend

Dear Peyronie's Disease UK,

I have just done a google search and came across your Peyronies site.
I noticed, completely out of the blue, a bend in my penis in September. It was a shock.
Since then have been to doc who referred me to Preston hospital, where the consultant said to leave it 6 months and then see him again.
He did say, somewhat casually, I might try vitamin E and Ibuprofen, but didn't say what kind of doses?
Good wishes, and trying to keep in good spirits.

A

--------------

Hi A,

My advice to you would be to try to get on pentoxifylline (aka trental). This is a drug that has shown at least some promise in the treatment of peyronie's disease. The consultants advice wasn't very useful in my opinion.

As pentoxifylline has shown to be useful in some men so I'd stick with that for 6 months to a year and then re-evaluate the situation. Perhaps the bend will improve somewhat over the period. In either case, if it is stable at not painful at a year to 18 months after injury and is still quite severe it may be worth trying to get surgery on the NHS.

Use of a VED or traction device may also be something you wish to explore. As a fellow sufferer, I undestand how difficult this condition can be to deal with. Keep your chin up. It might be worth your time to check out the peyronies disease forum. Talking through issues with those in similiar positions can often be helpful.

Regards,

Peyronie's Disease UK

Wednesday, 8 December 2010

Email - Peyronie's Disease Concern

Dear Peyronie's Disease UK,

I first discovered or heard about peyronie's disease around 2 months ago. I noticed a bend out of nowhere after a particularly stressful week and researched on the internet. For the first month I went into a state of shock and didn't do anything about it apart from worry as it seemed no one could help. I started taking VIT- E 400mg, Potaba (6 a day). MSM sulphur and using other herbal remedy's such as knotgrass which apparantly improves elasticity in tissues also using VIT- E oil, started quite regimented but of late have been very hap-hazard.

I found my urologist to be very friendly, he has put me forward for a MRI scan on the NHS. However I still feel very frustrated at the lack of any kind of schedule to stick to, it just seems there's a make it up as you go along approach. I'm aware your e-mail is there mainly for people to contribute rather than advice but i'm only 25 and just seem to be going round in circles.

Given my age, nature and stage of my condition assuming it could be peyronie's, what would you recommend? Looking back I have always suffered some kind of ED without ever really doing anything about it, would the PAV cocktail and VED be a good option? If so what kind of dosage would you recommend? Also whats the best dosage of VIT-E. Would you suggest taking VIT-C as well?

Would be a great relief to hear from you even if its just a message to repeat whats on your site. Its great to see someone like yourself taking positive action.

Best Regards,

C


-----


Hi C,

It is very hard to know how the condition will develop at this stage since you're only two months in. In some men the condition will remain stable, in others it will worsen, and in a lucky few it is thought to spontanesouly resolve. I would say that in six-ten months if your condition is the same as it is now, it's quite unlikely to worsen. I say this because urologists usually wait around a year before considering surgery. With the right treatment approach, you can hopefully stack the odds in your favour.

The PAV cocktail is used by Dr Levine and Dr Lue. Both world renowned in the field of peyronie's disease. The most effective part of the PAV cocktail is pentoxifylline. I posted a study which is perhaps the most promising peyronie's disease oral treatment study ever (not as though there is much competition for that title! - aside from the new COQ10 study). It's certainly not a miracle cure, and in some men no oral treatments will help, but the study suggests that pentoxifylline can help to stop progression of the condition in many men, and can improve the condition of some. It's a prescription medication (as is the Viagra part of the cocktail). The 'A' in PAV cocktail, L-arginine is available from health stores like Holland and Barrett and is very cheap.

I don't think Vitamin C will be of most use, so personally I wouldn't bother to take it. I'm not convinced that Vitamin E is very useful either, but it has been stacked with Pentoxifylline in some fibrosis studies, so perhaps it serves a purpose in that combination. A full spectrum vitamin E might be a better option than one from a local chemist. This kind of thing.

I wouldn't dissuade you from going the VED route. A multi pronged approach can pay dividends. Traction has also been demonstrated to reduce curvature somewhat in a study from a year or two back. There's not really a right way or wrong way to approach treatment, but while the condition is still active is makes sense to channel your efforts in a positive fashion.

Thanks,

Peyronie's Disease UK

Saturday, 4 December 2010

Email - Spontaneous Recovery

Dear Peyronie's Disease UK,

Thank you for your blog site. It's very helpful in its clear, concise but comprehensive nature. I'm a relatively new, young sufferer (29) and not dealing very well with the psychological implications. Do you think spontaneous recovery is valid? I don't believe your site directly addresses the issue, and statics on the Internet vary significantly with no real detail or case examples. Keep in mind that holding on to the idea of spontaneous recovery is very important to those early sufferers for whom hope is fragile.

Thank you, again, for your site, you are greatly appreciated by your readers.

M
-----

Hi M,

You've reminded me to write one or two posts about the psychological angle in future. I have heard of a few anecdotal reports of spontaneous recovery online. I'd prefer the term spontaneous improvement though (rather than recovery), as it seems more realistic than complete recovery. In taking a proactive approach towards treatment (Pentoxifylline, VED, Traction etc) I feel that it's possible for many men to make good improvements. It isn't an overnight answer though, a long term view is required. Once the condition is stable, there are options such as surgery, but if conservative treatments are somewhat successful, or improvements occur on their own, surgery may not be required.

Thanks,

Peyronie's Disease UK