Thursday, 12 November 2009

Pentoxifylline Study Update

Last week I posted an abstract from a new and rather exciting pentoxifylline study. Well thankfully the study is now available to be viewed click here. It's very detailed pdf document, but is a fascinating read. I would advise you to take the study to your urologist if he does not appear to be keen on prescribing pentoxifylline.

Some of the doctors involved in this study (Mohammad Reza Safarinejad etc) have carried out other peyronie's disease studies in the past, using Omega 3,vitamin E and propionyl-L-carnitine. None of these studies have had positive outcomes. In a sense I'm not disappointed by that fact though, because it shows that there is a genuine curiosity to find out what works and what doesn't for peyronie's disease, and not a desire to push a specific outcome.

If I had a wishlist, I'd quite like to see:

- Another study solidifying these findings
- A PAV cocktail study
- A study on men with very long term peyronie's (5 years+) to see if there is any difference in impovement rate
- A similiar study to this but with 400mg taken 3 or 4 times daily, instead of twice daily
- A two year study (this study suggested that the improvements gradually and constantly increased during treatment period. It'd be good to see where the end point of those improvements is. Looking at pentox use for other conditions it could be 6 - 12 month).

This pentoxifylline study really is good news, and for those very recently diagnosed there may een be additinal benefits not seen in this study. It's certainly not a cure, and it doesn't work for everyone, but pentoxifylline does appear to hinder progress of the disease in most men, and bring about noticable improvements in some.

Monday, 9 November 2009

Penis Tissue Replaced in the Lab

Of course in the here and now, potential peyronie's disease treatments five or ten years down the line might not be music to our ears, but the long game is a valid one. There are treatments that effectively offer hope in the short term (such as the PAV cocktail), VED / traction use, treatments on the horizon such as Xiaflex, and surgical options. An interesting article from the BBC News website, detailing the process of creating new erectile tissue in the lab.

As peyronie's disease seems to differ for each individual, with varying degrees of worsening/improvement/pain and so on, it's useful to existing sufferers to have the hope of new developments in the pipeline. Young people especially, are very likely to benefit from developments such as these in coming years. Keeping an eye on future animal trials will no doubt be in our interest.

Knowledge in relation to peyronie's disease has been embarrassingly lacking for so very long, and while there is still much to be known, it's heartening to see various potential solutions and advancements making their way towards us.

Tuesday, 3 November 2009

New Pentoxifylline Study

In recent years pentoxifylline has been suggested as a peyronie's disease treatment. Top urologists often suggest the PAV cocktail (Pentoxifylline, L-Arginine and Viagra), though in many instances the push to get pentoxifylline recognised as a valid treatment option is patient rather than urologist driven.

Take a look at this study.


Until recently pentoxifylline studies had been very thin on the ground. In fact, to the best of my knowledge this is the first study as such (other than a previous case study on one man, and seperate comments made by Dr Lue). The study, shows that while it may well not be the 'answer' to peyronie's disease, pentoxifylline IS likely a useful treatment for those with early chronic Peyronie's disease. It doesn't help everybody, but when you consider the lack of other available oral options, it is the right path to take. More research is needed to confirm these findings, but make no mistake, this is good news, and hopefully urologists to take note.

The jury is still out on the extent that pentoxifylline helps those with well established peyronie's disease, but a study relating to breast cancer posted here previously does suggest that it's a possibility, and certainly worth giving it a try.

Researching Peyronie's Disease

Medical developments and breakthroughs happen all of the time and although peyronie's disease isn't exactly at the forefront of such progress, it pays to keep your finger on the pulse. It is of course sad that PD doesn't receive the attention that it most certainly deserves, but knowledge gained in areas relating to inflammation and scarring all help us to piece together the puzzle that this condition is, and gives hope that peyronie's disease will one day be a thing of the past.

The Xiaflex trials are ongoing. Over the next year or so, we should start to get a firm idea of whether it will be recognised as a viable treatment for peyronie's disease. Keep an eye on their press releases here.

The peyronie's forum offers a patients perspective and anything new on the horizon in relation of treatments finds its way here in no time at all. Keep an eye on the developmental drugs, alternative treatments and oral treatments boards for the latest thoughts and findings.

There are a handful of patient run peyronie's blogs/sites, some of which in my view are very negative. One of the few I do enjoy reading is Cure Peyronie's. It's updated with new editions a few times a year, and every update is very detailed and enlightening. The latest update relates to 'prostate cancer and peyronie's disease', and in my view is a must read for all men. An eye opening read to say the least. The previous update centered more on future developments.

Those in the anti-aging community attempt to find ways to combat age related issues. As inflammatory processes are at the core of many conditions and diseases, developments here may apply directly to peyronie's disease inflammation. The immInst.org forum is well worth checking out for the latest buzz on supplements (and dietary matters) which may apply to sufferers of peyronie's disease. The supplements board and Resveratrol sub-board are especially interesting. The website anti-aging firewalls, is also very detailed and very relevant.

Last but certainly not least is the National Center for Biotechnology Information site. Here you have access to the very latest research. Using the search feature intelligently by searching by condition, treatments, characteristics and so on, can sometimes lead you to into making treatment choices and/or somewhat educated leaps of faith. That afterall is what pentoxifylline was/is.