Wednesday, 14 October 2009

Superoxide Dismutase

Superoxide Dismutase holds interest in the treatment of peyronie's. Admittedly some studies have been more promising than others, but as part of a well rounded approach to attacking peyronie's disease, I can see logic in adding it to a treatment regimen. A "topical gel containing liposomally encapsulated recombinant human superoxide dismutase" mentioned in a couple of articles in relation to peyronie's disease isn't commercially available, but a Superoxide Dismutase supplement is (from iherb in the form of a dietary supplement called S.O.D).

An enhanced verison of Superoxide Dismutase from 'Life Extension' called GliSODin appears to be the most bio-available oral version at our disposal. (Wikipedia entry)

As stated previously taurine may be a useful addition to the peyronie's arsenal, and it does appear that taurine raises superoxide dismutase levels, so maybe it is useful in part due to this mechanism. Type "taurine" and "Superoxide Dismutase" together in http://www.ncbi.nlm.nih.gov/sites/entrez to see countless instances of this. (As an aside: If you take Taurine, you may want to add Niacin, as a few studies involving both have demonstrated success in various fibrotic conditions).

As it seems that the injectable version is out of reach, and to be honest the idea of repeatedly injecting substances into a peyronies penis probably isn't a great idea under most curcumstances anyway. Still, maybe the enhanced oral bioavailability version can be a good conpromise. Adding an oral version to a regime seems like a safe bet since it has anti inflammatory and anti fibrotic properties in a number of conditions. Without a full understanding of the ins and outs of peyronie's disease, the best appraoch is likely one that covers as many bases as possible.

Friday, 9 October 2009

Long Term Pentoxifylline Treatment / Rebound Effect

I do think that if people are going to go the pentoxifylline route, there is good reason to stick with it for quite some time. One study relating to breast cancer radiation treatment which resulted in fibrosis, showed that stopping pentoxifylline treatment too soon resulted in a rebound effect in the condition (http://www.ncbi.nlm.nih.gov/pubmed/16260695). Another recent study in rats with radiation induced heart disease shows the same thing: http://www.ncbi.nlm.nih.gov/pubmed/19306752

Interestingly, the first study relating to superficial radiation-induced fibrosis suggested that progress can be made with pentoxifylline over a period of years. Admittedly the biggest improvements are made over the first 6 months, but in the long-term useage group, patients continued make slight improvements for upto two years. This is something that goes against the "six months" recommendation of some urologists.

Of course we cannot state that fibrosis in peyronie's disease behaves the same as in other conditions, but improvement over years combined with the rebound effect issue suggests that if pentoxifylline does appear to be working for you at six months to a year, continuing to use it may ensure that the improvements stand the test of time. Of course if there is no improvement at one year, then the case for taking it is much less robust. I'd make an exception for that if the condition is still active though (inflammation still present), as that suggests that plaque formation is either actively occuring or is further down the line. In those with plaque present for many years, the breast cancer study does appear to suggest that in those cases, pentoxiflline can take much longer to show promise.

If you're new to peyronie's disease, it's important to know that getting on top of this condition in the very early stages is a very wise decision, and pentoxifylline should be part of that process. I cringe when I hear people say that their urologist proposes a "wait and see" approach. What exactly is to be gained from that?

Reminder: Pentoxiflynne has worked well with L-arginine and Viagra (or levitra/cialis) in animal models, and tends to be the oral treatment put forward by some of the leading urologists.

Saturday, 3 October 2009

Peyronie's Disease Forum

When my life was first impacted by peyronie's disease, there was no internet, well at least not for the majority of us. With no way to connect with other sufferers, an extra layer was added to what was already a very difficult situation to come to terms with. In 'real life' urologists are not always the most understanding people, because they are simply are not trained to deal with the mental anguish that can often accompany this condition. A partner may not always be able to understand where you are coming from either, and it may be difficult to confide in family and friends.

The peyronie's disease forum has become something of a psychological sanctuary for many men. It's a forum for sufferers of peyronie's disease with almost 3000 members and many more observers. The discussion driven emphasis on the experience of the patient is something that is quite unique and leads to valuable infomation quickly filtering through (such as who the best urologists are, the latests takes on treatment options etc). I certainly recommend checking it out, if only to take a look around and view the contributions of others.

It would of course be good to see more local people (as in United Kingdom residents) contributing their experiences with urologists, the NHS in general and so on at the PD forum. Sharing local knowledge can benefit all sufferers, and learning from the experiences of others is something that we should certainly aim to promote.

Click HERE to check out the peyronie's disease forum!